发明名称 |
MIXTURES OF POLYPEPTIDES, COMPOSITIONS CONTAINING AND PROCESSES FOR PREPARING SAME, AND USES THEREOF |
摘要 |
The invention provides a composition comprising a mixture of polypeptides, wherein each polypeptide (a) is a copolymer of the amino acids L-glutamic acid, L-alanine, L-tyrosine, and L-lysine, and (b) may be in the form of a pharmaceutically acceptable salt; and wherein in the mixture (i) the polypeptides have an average molecular weight in the range 13,500 to 18,500 daltons, (ii) 13% to 38% of the polypeptides have a diethylamide group instead of a carboxyl group present at one end thereof, and (iii) 68% of the polypeptides have a molecular weight between 7,000 and 41,000 daltons. In an embodiment, the average molecular weight is 16,000 daltons. The invention also provides a method of treating a human subject afflicted with a neurodegenerative disease comprising administering to the human subject a therapeutically effective amount of any of the disclosed compositions so as to thereby treat the human subject. |
申请公布号 |
HRP20160455(T1) |
申请公布日期 |
2016.07.15 |
申请号 |
HR2016P000455T |
申请日期 |
2016.04.28 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO., LTD. |
发明人 |
Pinchasi, Irit;Dolitzky, Ben-Zion;Frenkel, Anton;Schwartz, Michal;Arnon, Ruth;Aharoni, Rina |
分类号 |
C07K14/00;A61K38/02;A61P1/00;A61P25/28;A61P37/00 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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