发明名称 |
Inhibition of intracellular signal transduction by 14-3-3-binding peptides |
摘要 |
Compositions and methods for inhibition of the intracellular activation of a signal transducing protein comprising phosphoserine containing peptides derived from the Raf-1 protein are disclosed. The peptides bind to 14-3-3 protein and thereby prevent its association with the signal transducing peptide to block signal transduction. Also provided is an assay method for identifying a pharmacologic agent that can bind 14-3-3 protein and block signal transduction.
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申请公布号 |
US5948765(A) |
申请公布日期 |
1999.09.07 |
申请号 |
US19960616669 |
申请日期 |
1996.03.15 |
申请人 |
WASHINGTON UNIVERSITY |
发明人 |
SHAW, ANDREY S.;MUSLIN, ANTHONY J. |
分类号 |
A61K38/00;C12N9/12;(IPC1-7):A61K38/00;A61K38/08;A61K38/10 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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