发明名称 |
Asymmetric ring-closing metathesis reactions |
摘要 |
A composition and method for the catalytic conversion of a racemic mixture of dienes to a cyclic olefin by a ring-closing metathesis (RCM) reaction are disclosed. The composition, a transition metal complex with an M=C reaction site, contains a bidentate dialkoxide of at least 80% optical purity. Because the M=C reaction site is of a sufficient shape specificity, conferred in part by the dialkoxide of sufficient rigidity and an M=N-R<1> site, reacting the composition with a mixture of two enantiomeric dienes results in an olefin metathesis product that has at least a 50% enantiomeric excess of one enantiomer in the mixture. A method is also provided for reacting a composition with a racemic diene mixture to generate a metathesis product that has an enantiomeric excess of at least 50%. |
申请公布号 |
AU3301599(A) |
申请公布日期 |
1999.09.06 |
申请号 |
AU19990033015 |
申请日期 |
1999.02.19 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
RICHARD R. SCHROCK;JOHN B. ALEXANDER |
分类号 |
B01J31/12;B01J31/18;B01J31/22;B01J31/34;C07B61/00;C07C6/04;C07F7/18;C07F11/00 |
主分类号 |
B01J31/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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