| 发明名称 |
IMMUNOTHERAPY |
| 摘要 |
The invention provides an agent comprising: a cyclic peptide comprising a T cell antigen peptide; wherein in cyclised form the T cell antigen peptide is not capable of eliciting a T cell response; and wherein the T cell antigen peptide is rendered capable of eliciting a T cell response by selective cleavage of one or more cleavage sites in the cyclic peptide. The agent may be used to prevent or treat a condition characterised by the presence of unwanted cells. |
| 申请公布号 |
US2016206726(A1) |
申请公布日期 |
2016.07.21 |
| 申请号 |
US201514986046 |
申请日期 |
2015.12.31 |
| 申请人 |
The University of Birmingham |
发明人 |
Cobbold Mark;Millar David |
| 分类号 |
A61K39/12;A61K39/00 |
主分类号 |
A61K39/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An agent for preventing or treating a condition characterized by the presence of unwanted cells comprising:
a cyclic peptide comprising a T cell antigen peptide; wherein in cyclised form the T cell antigen peptide is not capable of eliciting a T cell response; and wherein the T cell antigen peptide is rendered capable of eliciting a T cell response by selective cleavage of one or more cleavage sites in the cyclic peptide in the vicinity of the unwanted cells. |
| 地址 |
Birmingham GB |
