1-aryl-1-hydroxy-2,3-diamino-propyl amines, 1-heteroaryl-1-hydroxy-2,3-diamino-propyl amines and related compounds having analgesic and/or immuno stimulant activity

摘要

Compounds of the formula;
where the variables have the meaning defined in the specification have analgesic and/or immunostimulant effect in mammals.

主权项

1. A compound having the formula where:
R3 is CO—R7 or CO—O—R7;R4 is CO—R8;R5 and R6 are independently selected from H, alkyl of 1 to 6 carbons and alkoxy of 1 to 6 carbons;R7 is H, benzyl, alkyl of 1 to 20 carbons substituted with and NH2 group, with a NHCOOalkyl or with an NH-COalkyl group where the alkyl group has 1 to 6 carbons, or R7 is aryl, heteroaryl, aryl-alkyl or heteroaryl-alkyl where the alkyl moiety is branched or unbranched and has 1 to 4 carbons, said aryl or heteroaryl groups being optionally substituted with 1 to 3 groups independently selected from the group consisting of halogen, alkyl of 1 to 6 carbons, alkoxy of 1 to 6 carbons and thioxy of 1 to 6 carbons;R8 is alkyl of 1 to 6 carbons; or any other pharmaceutically acceptable salt of said compound.