发明名称 |
EIN PROTEIN, DAS SPEZIFISCHE DNA-STRUKTUREN ERKENNT, UND SEINE VERWENDUNGEN |
摘要 |
DNA structure specific recognition protein of eukaryotic origin and DNA encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognizes and binds DNA damaged or modified by a drug (the anticancer drug, cis-diamminedichloroplatinum (II) or cisplatin) has been identified. |
申请公布号 |
DE69229681(D1) |
申请公布日期 |
1999.09.02 |
申请号 |
DE1992629681 |
申请日期 |
1992.12.18 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
DONAHUE, BRIAN;TONEY, JEFFREY;ESSIGMANN, JOHN;LIPPARD, STEPHEN;PIL, PIETER;BRUHN, SUZANNE;BROWN, STEVEN;KELLETT, PATTI |
分类号 |
C12N15/09;A61K38/00;C07K14/39;C07K14/435;C07K14/47;C07K16/00;C07K16/18;C12P21/02;C12P21/08;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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