METHOD AND DEVICE FOR TISSUE MODULATION

摘要

A tissue modulation device comprises an upper surface and a lower surface, the upper surface comprises a recessed region (920) adjacent to a raised region (910), wherein application of a first portion of a tissue to the raised region depresses the first portion of the tissue relative to a second portion of the tissue that is in apposition to the recessed region (920). An optically transparent region of the device is curved at the lower surface to substantially reduce backscattered light in a light path traveling through the optically transparent region to a light collection system. A method of noninvasive spectroscopic measurement of an analyte in a subject comprises applying tissue of the subject to the tissue modulation device so that the raised region depresses a first portion of tissue relative to a second portion of tissue in apposition to the recessed region; irradiating the tissue in a blood-replete and a blood-depleted state with electromagnetic radiation; and analyzing the collected spectra to determine a concentration of analyte present in the tissue, by determining the difference between the spectra of the blood-replete and blood-depleted states.