TRANSGENIC MOUSE HAVING A LacZ REPORTER GENE UNDER THE CONTROL OF THE N-CAM PROMOTER USEFUL FOR IDENTIFYING N-CAM MODULATORS, METHODS AND COMPOSITIONS

摘要

The invention describes a transgenic mouse having a knockout N-CAM allele with an insertion of a reporter gene under the control of the N-CAM promoter. In preferred embodiments, the reporter gene encodes beta-galactosidase. The invention also describes methods for detecting modulators of the N-CAM gene using the transgenic mouse, or cultured cells obtained from the mouse.