发明名称 |
G PROTEIN-COUPLED RECEPTOR ANTAGONISTS |
摘要 |
G-protein coupled receptors (GPCR) generally contain seven transmembrane helices. The present invention provides synthetic peptides derived from these transmembrane helices. The peptides inhibit GPCR function by disrupting GPCR structure. In certain embodiments, charged residues are added at one terminus to promote correct orientation of the peptide in the membrane.
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申请公布号 |
CA2321962(A1) |
申请公布日期 |
1999.09.02 |
申请号 |
CA19992321962 |
申请日期 |
1999.02.26 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY, THE SECR ETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
MICHEJDA, CHRISTOPHER J.;TARASOVA, NADYA I. |
分类号 |
A61K38/00;C07K14/715;(IPC1-7):C07K14/715;A61K38/19 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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