发明名称 |
CROSS-LINKED HIGH AMYLOSE STARCH HAVING FUNCTIONAL GROUPS AS A MATRIX FOR THE SLOW RELEASE OF PHARMACEUTICAL AGENTS |
摘要 |
The present invention relates to a solid slow release oral pharmaceutical dosage unit resistant to amylase which comprises a solid dosage unit made up of an admixture of a therapeutic dosage of an orally effective pharmaceutical agent, an optional polysaccharide or polyol, and high amylose starch, wherein the cross-linking of the high amylose starch has been carried out with a crosslinking agent with from about 0.1 g to about 40 g of cross-linking agent per 100 g of high amylose starch. In a preferred embodiment of the invention, the high amylose starch is modified with a functional group-attaching reagent that covalently bonds functional groups thereto.
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申请公布号 |
CA2321461(A1) |
申请公布日期 |
1999.09.02 |
申请号 |
CA19992321461 |
申请日期 |
1999.02.24 |
申请人 |
MATEESCU, MIRCEA A.;CHOUINARD, FRANCOIS;ISPAS-SZABO, POMPILIA;LENAERTS, VINCENT |
发明人 |
MATEESCU, MIRCEA A.;CHOUINARD, FRANCOIS;ISPAS-SZABO, POMPILIA;LENAERTS, VINCENT |
分类号 |
A61K9/20;A61K9/22;A61K9/26;A61K31/137;A61K31/167;A61K31/192;A61K47/10;A61K47/34;A61K47/36;C08B33/00;C08B35/00;(IPC1-7):A61K9/20 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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