| 摘要 |
<p>Imidazoquinazoline derivatives represented by general formula (I) or pharmacologically acceptable salts thereof which have a potent and selective effect of inhibiting cyclic guanosine 3', 5'-1 monophosphate (cGMP)-specific phosphodiesterase (PDE) and are useful in treating or ameliorating cardiovascular diseases such as thrombosis, angina pectoris, hypertension, heart failure and arteriosclerosis, asthma, sexual impotence, etc.; wherein R?1 and R2¿ are the same or different and each represents hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, etc., or R?1 and R2¿ may form together an optionally substituted, N-containing heterocycle; and -X1-X2-X3- represents -NR3-C(=O)-NH- (wherein R3 has the same meaning as that of R?1), -NR3¿-C(=S)-NH- (wherein R3 has the same meaning as that of R?1), -NR3¿-N=N- (wherein R3 has the same meaning as that of R1), etc.</p> |
