HUMAN MONOCLONAL ANTIBODIES CAPABLE OF OLIGOSPECIFICALLY RECOGNIZING THE MAJOR TUMOR-ASSOCIATED GANGLIOSIDES AND METHODS OF USE THEREOF

摘要

A human monoclonal antibody capable of recognizing major tumor-associated gangliosides was isolated, sequenced and characterized. The human monoclonal antibody and antigen binding fragments therein are useful for detecting tumor associated antigens, diagnosis of cancer cells expressing the antigens, and for therapeutic treatment of cancers.