DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME

摘要

Disclosed herein are methods of inhibiting a deubiquitinase (DUB) by contact with a compound of formula (I);

主权项

1. A compound having a formula (I):wherein
R1 and R3 are halo or hydrogen and R2 is hydrogen, with the proviso that at least one of R1 and R3 is halo, or R1 and R2 together form an aryl or heteroaryl ring, and R3 is halo or hydrogen; R4 is C2-C6alkyl or C1-C6alkylenearyl; and (a) one of R5 and R5′ is hydrogen and the other substituted alkoxy, or (b) each of R5 and R5′ is substituted alkoxy, or (c) when R1 and R2 together form a substituted aryl or optionally substituted heteroaryl ring, then R5 and R5′ can each be hydrogen;or a salt or solvate thereof.