ANTICANCER AGENTS AND PROCESS OF MAKING THEREOF

摘要

Provided herein are compositions and processes of making of anticancer compounds useful for cancer treatments. These cyclohexenone compounds show an unexpected result against certain cancer cells compared to their known analogs.

主权项

1. A compound of formula II: or a pharmaceutically acceptable salt, metabolite, solvate or prodrug thereof, wherein R is a hydrogen, C(═O)OR5, C(═O)R5, C(═O)NR5R6, or a C1-C12alkyl, R1 is C1-C12alkyl, NR5R6, OR5, SR5, or halogen; each of R2 and R3 independently is a hydrogen, an optionally substituted C1-C12alkyl or (CH2CH═C(CH3)(CH2))m—R4, wherein R4 is H, NR5R6, OR5, OC(═O)R7, C(═O)OR5, C(═O)R5, C(═O)NR5R6, halogen, 5 or 6-membered lactone, C1-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, aryl, glucosyl, wherein the 5 or 6-membered lactone, C1-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, aryl, and glucosyl are optionally substituted with one or more substituents selected from NR5R6, OR5, OC(═O)R7, C(═O)OR5, C(═O)R5, C(═O)NR5R6, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, and C1-C8 haloalkyl; each of R5 and R6 is independently H or C1-C8alkyl; R7 is a C1-C8alkyl, OR5 or NR5R6; m=0-11.