USE OF SKIN PENETRATION ENHANCERS AND BARRIER DISRUPTION AGENTS TO ENHANCE THE TRANSCUTANEOUS IMMUNE RESPONSE INDUCED BY ADP-RIBOSYLATING EXOTOXIN

摘要

A transcutaneous immunization system where the topical application of an adjuvant and an antigen or nucleic acid encoding for an antigen, to intact skin induces a systemic or mucosal antibody response. The immune response so elicited can be enhanced by physical or chemical skin penetration enhancement.