Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
申请公布号
WO9840052(A9)
申请公布日期
1999.09.02
申请号
WO1998US04891
申请日期
1998.03.12
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;MCDONALD, DONALD, M.;MCLEAN, JOHN;THURSTON, O., GAVIN;BALUK, PETER
发明人
MCDONALD, DONALD, M.;MCLEAN, JOHN;THURSTON, O., GAVIN;BALUK, PETER