Process for producing crosslinked hyaluronic acid

摘要

A process for producing crosslinked hyaluronic acid (HA) or a salt thereof is disclosed, in which an aqueous solution of HA is crosslinked with divinyl sulphone (DVS) at a pH between 8 and 11 using a molar ratio of DVS/HA between 1 and 10%. The process results in a viscous aqueous solution of crosslinked hyaluronic acid or salt thereof, which is suitable for viscosupplementation of joints, especially for racing horses.