MONOCLONAL ANTIBODY TO HUMAN BETA 2 INTEGRIN ALPHA SUBUNIT

摘要

DNA encoding a novel human .beta.2 integrin .alpha. subunit polypeptide, designated .alpha.d, is disclosed along with methods and materials for production of the same by recombinant procedures. Fusion proteins are also disclosed which include extracellular .alpha.d protein fragments, .alpha.d I domain fragments or full length .alpha.d polypeptides and human immunoglobulin constant regions. Binding molecules specific for .alpha.d are also disclosed as useful for modulating the biological activities of .alpha.d. DNA from other species which show homology to human .alpha.d encoding sequences are also disclosed. Monoclonal antibodies immunospecific for .alpha.d are also disclosed.