INHIBITORS OF METALLOPROTEINASE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, THEIR PHARMACEUTICAL APPLICATION AND METHODS AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARATION

摘要

The invention relates to compounds with the formulawhere Z is O or S, V is bivalent radical which together with C*and N forms a ring containing 6 ring atoms, each of these atomsbeing different from C* and N, independently from each other inunsubstituted or substituted by a suitable substituent and atleast one of these other ring atoms is heteroatom selected from O,N & S, and the remaining being carbon atoms, Ar is aryl orheteroaryl group. The invention also relates to pharmaceuticallyacceptable promedicamentous forms, salts and solvates of thesecompounds, as well as to the method for the inhibition of theactivity of the metalloproteinases by the application of the abovecompounds or their promedicamentous forms or salts, or solvates.The invention also relates to pharmaceutical compositionscontaining an effective quantity of the compounds, thepromedicamentous forms, their salts or solvates, as well as to themethods and the intermediate compounds for their preparation.89 claims