| 摘要 |
PROBLEM TO BE SOLVED: To obtain an isolated polypeptide CYP7 promotor binding factor which can regulate activation of transcription, and is useful for screening of pharmacological substances, diagnosis, and treatment by making the isolated polypeptide include a specific amino acid sequence. SOLUTION: This factor is obtained by including the sequence shown by formula I, II, or III, or at least ten-residue domain of formula I containing at least one of residues 1-10, 11-15, 16-21, 204-207, and 299-307, ten-residue domain of formula II containing residue 154, or ten-residue domain of formula III containing at least one of residues 3-10, 13-22, and 30-38. It is preferable that the domain binds specifically with CYP7 gene promotor, and that SPF polypeptide is produced by culturing host cells transformed by a vector containing a recombinant nucleic acid coding for the isolated polypeptide. |
