| 摘要 |
PURPOSE:To produce the title substance useful as an intermediate for medicines, agricultural chemicals, etc., in high yield by reacting an aliphatic dicarboxylic acid with an alcohol in the presence of an acidic catalyst in the coexistence of an aliphatic dicarboxylic acid diester without using water. CONSTITUTION:A compound expressed by formula I (n and m are integers of 1-4; the symbol of bond indicates single, double or triple bond) is reacted with a compound expressed by formula II (R is 1-6C alkyl) used at 1:(0.7-1.4) molar ratio in the presence of an acidic catalyst (e.g. toluenesulfonic acid or sulfuric acid) in the coexistence of a compound expressed by formula III in a molar amount of 0.3-1.3 times based on the compound expressed by formula I in an organic solvent (e.g., toluene) at 60-120 deg.C to produce the objective compound expressed by formula IV. The aforementioned reaction is carried out without adding water. The compound expressed by formula IV can be produced in high yield by enhancing the conversion rate of the compound expressed by formula I and suppressing the formation of the compound expressed by formula III as a by-product. |
