发明名称 |
Methods of synthesizing gm3 |
摘要 |
The invention describes an improved method for making monosialoganglioside GM3 and its intermediates. Following reaction of a neuraminic acid donor and a lactose acceptor in the presence of an acid catalyst, the alpha and beta isomers of GM3 are formed. The alpha isomer is converted to a lactone, via action of a ring forming basic catalyst, which is then separable from the beta isomer. The lactone is then treated with a basic catalyst in the presence of an alcohol, to form GM3 or a GM3 intermediate. |
申请公布号 |
AU3297599(A) |
申请公布日期 |
1999.08.30 |
申请号 |
AU19990032975 |
申请日期 |
1999.02.17 |
申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
RICHARD SCHMIDT;JULIO C. CASTRO-PALOMINO;GERD RITTER;LLOYD J. OLD |
分类号 |
C07H15/10;A61P35/00;A61P37/02;C07B61/00;C07H1/00;C07H3/06;C07H13/04;C07H15/18 |
主分类号 |
C07H15/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|