| 发明名称 |
PROCESS FOR GENERATION OF HUMAN INSULIN |
| 摘要 |
A new method for the prodn. of recombinant human insulin comprises: folding a hybrid polypeptide comprising proinsulin under conditions that permit correct disulphide bond formation; subjecting folded protein to enzymatic cleavage and purifying produced. Also new is polypeptide that contains a leader peptide attached to the N terminus of, is folded and contains correct disulphide bonds. |
| 申请公布号 |
HUT78070(A) |
申请公布日期 |
1999.08.30 |
| 申请号 |
HU19980000292 |
申请日期 |
1994.12.29 |
| 申请人 |
BIO-TECHNOLOGY GENERAL CORP. |
发明人 |
GORECKI,MARIAN;HARTMAN,JACOB R.;MENDELOVITZ,SIMONA |
| 分类号 |
C12N15/09;A61K38/00;A61K38/28;A61P3/10;C07K1/107;C07K1/113;C07K14/62;C12N15/17;C12P21/00;C12P21/02;C12P21/06;C12R1/19 |
主分类号 |
C12N15/09 |
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