发明名称 |
Method for removing the protecting group for hydroxy group |
摘要 |
<p>A method for removing tri-substituted silyl group from beta -lactam compound having a tri-substituted silyl group-protecting hydroxy group, which comprises treating with an acid and a fluoride selected from alkali metal fluoride, alkaline earth metal fluoride and hydrogenfluoride of organic or inorganic amine, by which the tri-substituted silyl group can be easily and effectively removed under moderate conditions so that the desired compound can be obtained in high yield at low cost.</p> |
申请公布号 |
EP0937725(A2) |
申请公布日期 |
1999.08.25 |
申请号 |
EP19980123512 |
申请日期 |
1993.04.23 |
申请人 |
TANABE SEIYAKU CO., LTD. |
发明人 |
HORIKAWA, HIROSHI;KONDO, KAZUHIKO;IWASAKI, TAMEO |
分类号 |
C07D205/08;C07D463/00;C07D477/02;C07D499/88;C07D501/00;C07D503/00;C07D505/00;(IPC1-7):C07D477/00;C07D487/04 |
主分类号 |
C07D205/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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