| 摘要 |
The subject matter comprises anti-infective materials such as antimicrobial materials based upon poly(hexamethylene)biguanide having a weight proportion of said polymer containing 5 or less units per chain is less than 2% based on entire polymer weight, which are suitably in the form of a wound antiseptic and/or a wound treating material or a material for anti-microbial, antiviral, and/or antiparasitic treatment which may suitably be administered by the intravenous mode. The utilization concentration of the poly(hexamethylene)biguanide as a wound antiseptic and/or a wound treatment material suitably lies in the range of 0.001 through 0.05 wt. %, in particular 0.005 through 0.012 wt. %. As compared to the known disinfective materials based upon poly(hexamethylene)biguanide which have been utilized as wound antiseptics and wound treatment materials, the poly-(hexamethylene)biguanides utilized in the present invention have a higher mean molecular weight and demonstrate an increased microbicidal activity coupled with lower toxicity and are free of side effects on the central nervous system.
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