| 摘要 |
PROBLEM TO BE SOLVED: To obtain a novel polynucleotide having high identity to a nucleic acid encoding for a polypeptide containing a specific amino acid sequence and used for the screening of antibiotic activities, the treatment and prevention, etc., of Staphylococcus aureus infections. SOLUTION: The novel GAPDH is a newly isolated polynucleotide consisting of a polynucleotide having at least 70% identity to the polynucleotide encoding for the polypeptide containing the amino acid sequence of the formula, a polynucleotide having at least 70% identity to a polynucleotide encoding the ripen polypeptide equal to that expressed by the GAPDH gene included in a deposited strain, Staphylococcus aureus, and the like, and useful for the screening of compounds associated with antibiotic activities and treatment, diagnosis, etc. of Staphylococcus aureus infections. This polynucleotide is obtained by probing a chromosome DNA library of Staphylococcus aureus with an oligonucleotide derived from a partial sequence. |
