| 摘要 |
Disclosed is a pharmaceutical composition for treating bone loss in a mammal comprising a therapeutically effective amount of leptin or a leptin mimetic. Also disclosed is a pharmaceutical composition for treating bone fracture, enhancing bone healing following facial reconstruction, maxillary reconstruction or madibular reconstruction, enhancing long bone extension, enhancing the healing rate of a bone graft, enhancing prosthetic growth and inducing vertebral. synostosis, comprising a therapeutically effective amount of leptin or a leptin mimetic. Still further disclosed is a pharmaceutical composition comprising leptin or a leptin mimetic and estrogen, a selective estrogen receptor modulator or a bisphosphonate for treating the above-recited diseases and conditions.
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