| 发明名称 |
Tryptase inhibitors |
| 摘要 |
The invention relates to bifunctional tryptase inhibitors of formula (I)wherein H1 and H2 comprise a Q group and L is a linker of formulaand the conformation of the H1, H2 and L groups is such that the groups are separated by a distance of from 20 to 45 Å. Pharmaceutical compositions and crystal forms of the compounds are described in addition to methods for producing and identifying such compounds, as well as the use of such compounds in methods of treating allergic and inflammatory diseases. |
| 申请公布号 |
AU2723099(A) |
申请公布日期 |
1999.08.23 |
| 申请号 |
AU19990027230 |
申请日期 |
1999.02.04 |
| 申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.;BYK GULDEN LOMBERG CHEMISCHE FABRIK G.M.B.H. |
发明人 |
WOLFRAM BODE;LUIS MORODER;PEDRO JOSE BARBOSA PEREIRA;ANDREAS BERGNER;ROBERT HUBER;CHRISTIAN SOMMERHOFF;NORBERT SCHASCHKE;THOMAS BAR;THOMAS MARTIN;JOSEF STADLWIESER;WOLF-RUDIGER ULRICH;ANDREAS DOMINIK;ULRICH THIBAUT;DANIELA BUNDSCHUH;ROLF BEUME;KARL-JOSEF GOEBEL |
| 分类号 |
C07D295/20;A61K31/165;A61K31/44;A61K31/4402;A61K31/4418;A61K31/4427;A61K31/445;A61K31/4468;A61K31/4545;A61K31/495;A61K31/496;A61K31/4985;A61P1/02;A61P11/06;A61P17/00;A61P17/06;A61P19/06;A61P27/16;A61P29/00;A61P37/08;A61P43/00;C07C237/10;C07C237/22;C07C279/16;C07C279/18;C07D211/58;C07D213/81;C07D213/82;C07D241/08;C07D295/185;C07D295/215;C07D401/14;C07D487/14 |
主分类号 |
C07D295/20 |
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