| 发明名称 |
HYDROXYLATION ACTIVATED DRUG RELEASE |
| 摘要 |
The present invention concerns prodrugs whose aromatic oxidation, particularly their enzymatic aromatic hydroxylation, results in their activation by the release of a drug moiety. It particularly concerns anti-tumour prodrugs and those which are specifically activated by the hydroxylation activity of the P450 enzyme CYP1B1. Also provided are methods of detection of aromatic oxidation activity.
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| 申请公布号 |
CA2319837(A1) |
申请公布日期 |
1999.08.19 |
| 申请号 |
CA19992319837 |
申请日期 |
1999.02.10 |
| 申请人 |
DE MONTFORT UNIVERSITY |
发明人 |
BURKE, MICHAEL DANNY;PATTERSON, LAWRENCE HYLTON;POTTER, GERARD ANDREW |
| 分类号 |
A61K47/48;A46B9/04;A61K31/27;A61K31/337;A61K31/37;A61K31/505;A61K31/513;A61K31/535;A61K31/536;A61K31/565;A61K31/70;A61K31/704;A61P35/00;A61P43/00;G07F17/30;(IPC1-7):A61K31/565 |
主分类号 |
A61K47/48 |
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