| 发明名称 |
METHODS AND REAGENTS FOR THE RAPID AND EFFICIENT ISOLATION OF CIRCULATING CANCER CELLS |
| 摘要 |
A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater sensitivety than conventional PCR or immunohistochemistry by 1-2 orders of magnitude. In addition, the assay facilitates the biological characterization and staging of carcinoma cells. |
| 申请公布号 |
CA2320418(A1) |
申请公布日期 |
1999.08.19 |
| 申请号 |
CA19992320418 |
申请日期 |
1999.02.12 |
| 申请人 |
THE UNIVERSITY OF TEXAS SYSTEM;IMMUNIVEST AND BOARD OF REGENTS |
发明人 |
RACILA, EMILIAN V.;RAO, GALLA CHANDRA;TERSTAPPEN, LEON W.M.M.;UHR, JONATHAN W.;LIBERTI, PAUL A. |
| 分类号 |
G01N33/58;B03C1/01;C12Q1/02;C12Q1/06;C12Q1/24;G01N33/48;G01N33/53;G01N33/543;G01N33/574;H01F1/00;(IPC1-7):G01N33/58;G01N33/49 |
主分类号 |
G01N33/58 |
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