发明名称 |
STRATEGICALLY MODIFIED HEPATITIS B CORE PROTEINS AND THEIR DERIVATIVES |
摘要 |
A strategically modified hepatitis B core protein is described, where an insert is provided, preferably in an immunodominant region of the nucleocapsid protein, containing a chemically reactive amino acid residue. The modified hepatitis B core protein or its aggregated nucleocapsid protein particles can be pendently linked to a hapten to form a modified nucleocapsid conjugate. Such a conjugate is useful in the preparation of vaccines or antibodies. The modified hepatitis B core protein can also be modified to include a T cell epitope.
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申请公布号 |
WO9940934(A1) |
申请公布日期 |
1999.08.19 |
申请号 |
WO1999US03055 |
申请日期 |
1999.02.11 |
申请人 |
IMMUNE COMPLEX, CORPORATION |
发明人 |
BIRKETT, ASHLEY, J. |
分类号 |
C12N15/09;A61K39/00;A61K39/29;A61K39/38;A61K39/39;A61P31/04;A61P31/20;C07K7/00;C07K14/02;C07K16/00;C12N9/02;(IPC1-7):A61K39/00;C07K15/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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