| 摘要 |
<p>Novel amidino derivatives represented by general formula (I) which have an inhibitory effect on blood coagulation factor VIIa and are useful as preventives and/or remedies for various vascular lesions associating accelerated coagulation activity, for example, universal intravascular coagulation syndrome, coronary thrombosis, brain infarction, brain embolism, transient cerebral ischemic attack, diseases associating cerebral vascular disorders, deep vein thrombosis, peripheral embolism, thrombus formation following artificial blood vessel operation or artificial valve replacement, diseases associating postoperative thrombus formation, reobstruction and reconstriction following coronary artery bypass, reobstruction and reconstriction following PTCA or PTCR, thrombus formation during extracorporeal circulation and glomerulonephritis. In formula (I) each symbol has the meaning as defined in the specification.</p> |
