| 摘要 |
<p>The invention concerns a novel oral formulation with immediate release of morphine sulphate in the form of microgranules. Each microgranule comprises a neutral support grain coated with a mixture of morphine sulphate and a binding agent such as hydroxypropylmethylcellulose representing 10 to 50 wt. % of the morphine sulphate/binding agent mixture. The invention also concerns a method for preparing said microgranules produced entirely in aqueous medium on neutral support grains. The invention further concerns pharmaceutical preparations containing said microgranules.</p> |
