| 摘要 |
<p>The invention is directed to helper adenoviruses which facilitate the production of pseudoadenoviral vectors (PAV) but which cannot be packaged into viral particles. The invention is further directed to novel PAV producer cell lines expressing DNA binding and/or repressor proteins that prevent the packaging of the helper viruses. The invention is also directed to methods for the production of PAV in such cell lines with minimal contamination from helper viruses.</p> |
