CRYSTALLIZABLE COMPOSITIONS COMPRISING A HEPATITIS C VIRUS NS3 PROTEASE DOMAIN/NS4A COMPLEX AND CRYSTALS THEREBY OBTAINED
摘要
The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
申请公布号
EP0935609(A1)
申请公布日期
1999.08.18
申请号
EP19970942450
申请日期
1997.09.12
申请人
VERTEX PHARMACEUTICALS INCORPORATED
发明人
KIM, JOSEPH, L.;MORGENSTERN, KURT, A.;LIN, CHAO;FOX, TED;THOMSON, JOHN, A.