Pharmaceutical compositions containing NSAIDs and piperine

摘要

A novel composition for increasing the bioavailability of Non-steroidal Anti-inflammatory Drugs (NSAIDs) or derivatives thereof particularly those belonging to the category which exhibits its activity by selectively inhibiting cyclooxygenases-II (COX-II) and/or lipooxygenases is disclosed. The composition is characterised in having clinically significant increased bio-availability when compared to the known compositions of the drugs. The pharmaceutical compositions comprise NSAIDs and/or derivatives thereof and Piperine, its metabolites, structural analogues or isomers of Piperine. Enhanced bio-availability results in the reduction of the dose of NSAIDs or derivatives thereof and hence will reduce the cost of therapy in diseases like arthritis which require long term therapies which results from the high cost of the drugs. Also as the cost of therapy will decrease, NSAIDs such as Nimesulide can be put to much wider use in newer indications. Enhanced bio-availability of NSAIDs results in the reduction of dose-related side effects.