发明名称 |
Chimeric fatty body-pro-GRF (1-29) analogs with increased biological potency |
摘要 |
The present invention relates to chimeric fatty body-pro-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-pro-GRF analogs include an hydrophobic moiety (tail), and can be prepared, either by anchoring one or several hydrophobic tails to the GRF, or by substituting one or several amino-acids by a pseudomicellar residue in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.
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申请公布号 |
US5939386(A) |
申请公布日期 |
1999.08.17 |
申请号 |
US19960702113 |
申请日期 |
1996.08.23 |
申请人 |
THERATECHNOLOGIES INC. |
发明人 |
IBEA, MICHEL;ABRIBAT, THIERRY;BRAZEAU, PAUL |
分类号 |
A61K38/00;A61K38/22;A61P3/02;A61P5/02;A61P43/00;C07K14/60;C07K19/00;G01N33/68;(IPC1-7):A61K38/25 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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