Method of evaluating an effect of a substance applied to the skin of a mammal

摘要

PCT No. PCT/AU97/00300 Sec. 371 Date Mar. 17, 1998 Sec. 102(e) Date Mar. 17, 1998 PCT Filed May 16, 1997 PCT Pub. No. WO97/44066 PCT Pub. Date Nov. 27, 1997A method for evaluating an effect of a substance when applied to mammalian skin is provided. The method comprises the steps of: (i) assessing an immune response of the skin of at least one mammal to an antigen, to which the mammal has been sensitized, in order to obtain data; (ii) applying the substance to the skin; (iii) assessing the immune response of the skin to the antigen following the application of the substance to the skin to obtain further data; and (iv) using the data obtained in steps (i) and (iii) to evaluate the effect of the substance.