发明名称 |
Asymmetric fluorine-containing primary amines and their preparation |
摘要 |
The present invention, which is aimed at providing a novel reaction for converting a fluorine-containing carbonyl compound to an asymmetric fluorine-containing primary amine, relates to a method in which a Schiff base obtained by the condensation of a fluorine-containing carbonyl compound and an asymmetric amine ((S)- or (R)-1-phenylethylamine) is treated in the presence of an appropriate organic base to hydrolyze a tautomeric imine obtained by asymmetrically performing an enzyme-like transamination reaction, yielding an asymmetric fluorine-containing amine.
|
申请公布号 |
US5939588(A) |
申请公布日期 |
1999.08.17 |
申请号 |
US19970992085 |
申请日期 |
1997.12.17 |
申请人 |
AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY |
发明人 |
SOLOSHONOK, VADIM A.;ONO, TAIZO;ABE, TAKASHI |
分类号 |
C07B43/04;C07C209/62;C07C211/15;C07C211/29;C07C249/02;C07C251/08;C07C251/16;C07C251/24;(IPC1-7):C07C211/00 |
主分类号 |
C07B43/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|