| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new protein useful e.g. for the treatment of neurodegenerative disorders, such as ischemic cerebral disorders, Alzheime's disease and Parkinson's disease, having a specific amino acid sequence, consisting of a protein having an regulatory function for gene transcription and derived from human cerebral cortex. SOLUTION: This protein is a protein having an amino acid sequence described in the formula or a new protein HVCEP-4 having an amino acid sequence wherein one or several amino acids is (are) deleted, substituted or added in the amino acid sequence of the formula and consisting of a protein having a regulatory function for gene transcription, and useful e.g. as a therapeutic medicine for neurodegenerative disorders, such as ischemic cerebral disorders, Alzheimer's disease and Parkinson's disease. This protein is obtained by screening a cDNA library derived from human cerebral cortex through plaque hybridization using as a probe a cDNA fragment of hucep-4 labeled with digoxigenin, transforming host cells by incorporating the resultant hucep-4 into a vector and culturing this transformant. |
