发明名称 |
DNA vaccination for induction of suppressive T cell response |
摘要 |
A pro-inflammatory T response is specifically prevented by the injection into a recipient of DNA encoding the variable region of a T cell receptor. In response to the vaccination, T cells expressing the variable region produce Th2 cytokines, including IL-4. A pro-inflammatory T cell response directed to an autoantigen is shown to be suppressed by DNA vaccination. The suppressive vaccination further reduced the inflammatory effect of T cells reactive against epitopes of the autoantigen not recognized by the variable region used for vaccination.
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申请公布号 |
US5939400(A) |
申请公布日期 |
1999.08.17 |
申请号 |
US19960606639 |
申请日期 |
1996.02.26 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
STEINMAN, LAWRENCE;WAISMAN, ARI |
分类号 |
C12N15/09;A61K31/00;A61K31/70;A61K31/7088;A61K31/711;A61K38/00;A61K48/00;A61P29/00;A61P37/00;A61P37/06;C07K14/725;C12Q1/68;(IPC1-7):A01N43/04;C12N15/00;C12N15/63 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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