发明名称 |
Mammaglobin, a secreted mammary-specific breast cancer protein. |
摘要 |
A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor. |
申请公布号 |
ZA9808526(B) |
申请公布日期 |
1999.08.16 |
申请号 |
ZA19980008526 |
申请日期 |
1998.09.17 |
申请人 |
WASHINGTON UNIVERSITY |
发明人 |
MARK A. WATSON;TIMOTHY P. FLEMING |
分类号 |
C12N15/09;A61K35/26;A61K38/00;A61K39/00;A61K39/395;A61P35/00;C07K14/47 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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