DERIVATIVES OF PYRROLIDINE AND PIPERIDINE, METHOD OF OBTAINING THEM AND PHARMACEUTIC COMPOSITIONS CONTAINING SUCH DERIVATIVES

摘要

The present invention relates to the use of pyrrolidine and piperidine derivatives of the general formulae wherein R<1> and R<2> are, independently from each other, hydrogen, lower alkoxy, hydroxy, halogen, -CONH2 or -C(O)O-lower alkyl; or taken together are -O-CH2-O-; R<3> and R<4> are, independently from each other, hydrogen, lower alkoxy, benzyloxy, halogen, hydroxy, -CONH2 or -SCH3; or taken together are -O-CH2-O-; R<5> is hydrogen or lower alkyl; X and Y are, independently from each other -CH(OH)-, -(CH2)n-, -C(O)- or -CH(lower alkoxy)-; and m, n and p are 1 or 2; and to their pharmaceutically acceptable addition salts for the treatment of diseases caused by overactivation of NMDA receptor subtypes.