VERFAHREN ZUR HERSTELLUNG VON SUBSTITUIERTEN PHENOLEN

摘要

Prodn. of alkenyl-phenols of formula (I) comprises reacting a phenol of formula (II) with a butadiene deriv. of formula R1-C(=HC2)-CH=CH2 (III) in the presence of a base and a catalyst comprising Rh(I) and a diphosphine that is soluble in aprotic organic solvents. R = one or more gps. selected from H, OH and 1-6C alkyl; R' = a gp. of formula R1-C(=CH2)-CH2CH2- (IVa) or R1-C(Me)=CH-CH2- (IVb) contg. at least 6 C atoms; R1 = opt. substd. alkyl or alkenyl. Also claimed is the prodn. of vitamin E by (i) cyclising a cpd. of formula (Ia) in the presence of a catalyst selected from p-toluenesulphonic acid, Cl2AlMe, ZnCl2, Cl2AlOEt and triflates of Sc, Yb, La and Sn(II) and (ii) hydrogenating the prod.