SINGLE-CHAIN POLYPEPTIDES COMPRISING CREATINE KINASE M AND CREATINE KINASE B

摘要

This invention relates to single-chain polypeptides and their genetic sequences comprising creatine kinase M and creatine kinase B. The single-chain polypeptide may be expressed recombinantly. A linker peptide may be interposed between the creatine kinase sequences. A linker peptide of about 6 to about 50 amino acids is preferred. The single-chain polypeptide has utility as a control or calibrator for creatine kinase MB assays, for the purification of creatine kinase antibodies, and as an antigen for the preparation of antibodies.