OXO-DIPYRIDOIMIDAZOLE-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS

摘要

Disclosed are compounds of formula (I) or pharmaceutically acceptable non-toxic salts thereof wherein: (a) represents an optionally substituted nitrogen-containing ring system; R is defined herein; and G is an organic or inorganic group, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors, and are therefore useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, depression, overdose with benzodiazepine drugs and for enhancement of alertness.