| 摘要 |
<p>Nuclear factor kappa B (NF-λB) activation inhibitors focusing on a novel transfer molecule; preventives/remedies for autoimmune diseases, etc.; and novel methods for identifying or screening the same. A method for identifying or screening NF-λB activation inhibitors which involves the step of examining the effect of a test substance of modulating the function of TGF-β activated kinase 1 (TAK1); a method for identifying or screening remedies and/or preventives for autoimmune diseases or intractable diseases with inflammation which involves the step of examining the effect of a test substance of modulating the function of TAK1 in the NF-λB activation pathway; and novel NF-λB activation inhibitors, and remedies/preventives for autoimmune diseases, intractable diseases with inflammation, etc. which are screened or identified by the above methods.</p> |
