摘要 |
<p>Compounds of formula (I): <CHEM> [wherein R<1> represents a group of formula (II) or (III): <CHEM> R<2> is hydrogen or a group of formula -OR<3>; R<3>, R<3a> and R<3b> are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulphonyl, halogenated alkanesulphonyl or arylsulphonyl; R<4> is hydrogen or a carboxy-protecting group; R<5> is alkyl, alkenyl, alkynyl, aryl, aralkyl or a fused polycycle; and W is alkylene] and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.</p> |
申请人 |
SANKYO CO., LTD., TOKIO/TOKYO, JP |
发明人 |
ISHIHARA, SADAO, C/O SANKYO COMPANY LIMITED, TOKYO 140, JP;KOGEN, HIROSHI, C/O SANKYO COMPANY LIMITED, TOKYO 140, JP;KOGA, TEIICHIRO, C/O SANKYO COMPANY LIMITED, TOKYO 140, JP;KITAZAWA, EIICHI, C/O SANKYO COMPANY LIMITED, TOKYO 140, JP;SERIZAWA, NOBUFUSA, C/O SANKYO COMPANY LIMITE, TOKYO 140, JP |