| 摘要 |
<p>The present invention relates to a hydroalcoholic gel composition which not only can decrease the external loss of piroxicam but also can increase the permeation of piroxicam through skin remarkably, compared with conventional hydrogel preparation, by forming a film on the skin surface promptly without drug precipitation, using lower alkanol having from one to four carbon atoms as a main solvent. The composition according to the present invention comprises (a) 0.1∩2 % by weight of piroxicam; (b) 40∩60 % by weight of lower alkanol having from one to four carbon atoms; (c) 0.1∩5 % by weight of hydroxypropylcellulose or hydrophobic derivatives of hydroxypropylmethylcellulose, optionally comprising hydroxypropylmethylcellulose or carbomer, as a polymer vehicle; (d) 0.1∩20 % by weight of at least one absorption enhancer selected from the group consisting of diethyleneglycol monoethylether, polyoxyethyleneglycolated natural or hydrogenated castor oil, oleic acid and its alkali salt, and polysorbate; (e) 0.1∩5 % by weight of at least one pH controlling agent selected from alkanolamines; and (f) water.</p> |
