发明名称 |
METHOD FOR REGULATING SIZE AND GROWTH OF VASCULARIZED NORMAL TISSUE |
摘要 |
The present invention is directed generally to the field of treatment of obesity and other disorders characterized by proliferation of normal vascularized tissues, by the administration of effective amount of angiogenesis inhibitors. Angiogenesis inhibitors are administered to regulate normal, non-transformed vascularized tissue size and/or growth by regulating its vascular compartment. Examples of tissues that can be controlled include adipose tissue, intestinal polyps, muscle (including cardiac) tissue, endometrial tissue and prostate tissue. The inhibitor is selected from the group consisting of TNP-470, angiostatin, endostatin, and thalidomide.
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申请公布号 |
CA2307792(A1) |
申请公布日期 |
1999.08.12 |
申请号 |
CA19982307792 |
申请日期 |
1998.10.30 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
RUPNICK, MARIA;FOLKMAN, JUDAH;LANGER, ROBERT S. |
分类号 |
A61K45/00;A61K31/00;A61K31/336;A61K31/454;A61K38/00;A61K38/39;A61K38/48;A61K38/55;A61P3/04;A61P9/00;A61P13/08;A61P15/00;A61P35/00;A61P43/00;(IPC1-7):A61K31/335;A61K38/17;A61K31/445 |
主分类号 |
A61K45/00 |
代理机构 |
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地址 |
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